| Florence to Santeramo in Colle | 348.50 mi (560.86 km) |
| Florence to Santo Stefano di Magra | 71.87 mi (115.66 km) |
| Florence to Santo Stino di Livenza | 152.61 mi (245.60 km) |
| Florence to Sarezzo | 139.74 mi (224.88 km) |
| Florence to Sarno | 266.80 mi (429.38 km) |
| Florence to Saronno | 168.12 mi (270.56 km) |
| Florence to Sarzana | 68.59 mi (110.38 km) |
| Florence to Sassari | 251.47 mi (404.70 km) |
| Florence to Sasso Marconi | 43.43 mi (69.90 km) |
| Florence to Sassuolo | 58.70 mi (94.47 km) |
| Florence to Sava | 398.59 mi (641.47 km) |
| Florence to Saviano | 258.15 mi (415.44 km) |
| Florence to Savigliano | 189.30 mi (304.65 km) |
| Florence to Savignano sul Panaro | 50.39 mi (81.10 km) |
| Florence to Savignano sul Rubicone | 60.76 mi (97.78 km) |
