| Florence to Setubal | 1,105.76 mi (1,779.55 km) |
| Florence to Sever do Vouga | 1,022.59 mi (1,645.71 km) |
| Florence to Silves | 1,126.91 mi (1,813.59 km) |
| Florence to Sines | 1,121.93 mi (1,805.56 km) |
| Florence to Sintra | 1,121.97 mi (1,805.64 km) |
| Florence to Sobrado de Paiva | 1,011.28 mi (1,627.50 km) |
| Florence to Sobral de Monte Agraco | 1,104.19 mi (1,777.03 km) |
| Florence to Soure | 1,051.58 mi (1,692.36 km) |
| Florence to Tabua | 1,014.26 mi (1,632.29 km) |
| Florence to Tavira | 1,091.88 mi (1,757.20 km) |
| Florence to Tomar | 1,052.27 mi (1,693.46 km) |
| Florence to Tondela | 1,013.34 mi (1,630.81 km) |
| Florence to Torre de Moncorvo | 951.50 mi (1,531.30 km) |
| Florence to Torres Novas | 1,061.53 mi (1,708.36 km) |
| Florence to Torres Vedras | 1,108.01 mi (1,783.17 km) |
