| Florence to Sangeorz-Bai | 694.22 mi (1,117.24 km) |
| Florence to Sannicolau Mare | 484.13 mi (779.14 km) |
| Florence to Santana | 530.36 mi (853.53 km) |
| Florence to Satu Mare | 624.79 mi (1,005.51 km) |
| Florence to Scobinti | 796.63 mi (1,282.06 km) |
| Florence to Scornicesti | 660.49 mi (1,062.95 km) |
| Florence to Sebes | 621.08 mi (999.53 km) |
| Florence to Seini | 640.80 mi (1,031.27 km) |
| Florence to Sfantu-Gheorghe | 725.74 mi (1,167.96 km) |
| Florence to Sibiu | 646.99 mi (1,041.22 km) |
| Florence to Sighetu Marmatiei | 671.56 mi (1,080.78 km) |
| Florence to Sighisoara | 681.73 mi (1,097.14 km) |
| Florence to Simeria | 593.26 mi (954.76 km) |
| Florence to Sinaia | 711.27 mi (1,144.68 km) |
| Florence to Slatina | 651.37 mi (1,048.28 km) |
