| Florida to Southern Pines (North Carolina) | 1,403.91 mi (2,259.38 km) |
| Florida to Southfield (Michigan) | 1,932.27 mi (3,109.69 km) |
| Florida to Southgate (Michigan) | 1,915.38 mi (3,082.50 km) |
| Florida to Southlake (Texas) | 2,143.73 mi (3,450.00 km) |
| Florida to Spanaway (Washington) | 3,703.71 mi (5,960.55 km) |
| Florida to Spanish Fork (Utah) | 3,061.78 mi (4,927.46 km) |
| Florida to Spanish Lake (Missouri) | 2,000.42 mi (3,219.36 km) |
| Florida to Spanish Springs (Nevada) | 3,470.64 mi (5,585.45 km) |
| Florida to Sparks (Nevada) | 3,472.19 mi (5,587.95 km) |
| Florida to Spartanburg (South Carolina) | 1,483.32 mi (2,387.17 km) |
| Florida to Spearfish (South Dakota) | 2,802.71 mi (4,510.53 km) |
| Florida to Speedway (Indiana) | 1,889.47 mi (3,040.81 km) |
| Florida to Spencer (Iowa) | 2,388.37 mi (3,843.71 km) |
| Florida to Spokane (Washington) | 3,488.39 mi (5,614.02 km) |
| Florida to Spokane Valley (Washington) | 3,479.49 mi (5,599.70 km) |
