| Flower Mound to Southern Pines (North Carolina) | 1,022.64 mi (1,645.78 km) |
| Flower Mound to Southfield (Michigan) | 996.84 mi (1,604.26 km) |
| Flower Mound to Southgate (Michigan) | 988.12 mi (1,590.23 km) |
| Flower Mound to Southlake (Texas) | 5.89 mi (9.48 km) |
| Flower Mound to Spanaway (Washington) | 1,641.58 mi (2,641.86 km) |
| Flower Mound to Spanish Fork (Utah) | 940.89 mi (1,514.21 km) |
| Flower Mound to Spanish Lake (Missouri) | 554.14 mi (891.80 km) |
| Flower Mound to Spanish Springs (Nevada) | 1,331.58 mi (2,142.98 km) |
| Flower Mound to Sparks (Nevada) | 1,332.72 mi (2,144.81 km) |
| Flower Mound to Spartanburg (South Carolina) | 879.24 mi (1,415.00 km) |
| Flower Mound to Spearfish (South Dakota) | 869.24 mi (1,398.91 km) |
| Flower Mound to Speedway (Indiana) | 762.68 mi (1,227.41 km) |
| Flower Mound to Spencer (Iowa) | 706.74 mi (1,137.39 km) |
| Flower Mound to Spokane (Washington) | 1,463.55 mi (2,355.36 km) |
| Flower Mound to Spokane Valley (Washington) | 1,455.95 mi (2,343.12 km) |
