| Fort Myers to Enterprise (Nevada) | 2,063.61 mi (3,321.06 km) |
| Fort Myers to Enumclaw (Washington) | 2,593.47 mi (4,173.78 km) |
| Fort Myers to Ephrata (Pennsylvania) | 991.47 mi (1,595.62 km) |
| Fort Myers to Erie (Colorado) | 1,621.33 mi (2,609.27 km) |
| Fort Myers to Erie (Pennsylvania) | 1,075.37 mi (1,730.64 km) |
| Fort Myers to Erlanger (Kentucky) | 870.87 mi (1,401.53 km) |
| Fort Myers to Escanaba (Michigan) | 1,353.01 mi (2,177.47 km) |
| Fort Myers to Escondido (California) | 2,148.29 mi (3,457.34 km) |
| Fort Myers to Española (New Mexico) | 1,565.12 mi (2,518.82 km) |
| Fort Myers to Essex (Maryland) | 929.75 mi (1,496.28 km) |
| Fort Myers to Essex Junction (Vermont) | 1,326.48 mi (2,134.76 km) |
| Fort Myers to Estelle (Louisiana) | 550.45 mi (885.86 km) |
| Fort Myers to Estero (Florida) | 13.43 mi (21.61 km) |
| Fort Myers to Euclid (Ohio) | 1,034.54 mi (1,664.93 km) |
| Fort Myers to Eufaula (Alabama) | 416.69 mi (670.59 km) |
