| Fort Myers to Olympia Heights (Florida) | 111.26 mi (179.06 km) |
| Fort Myers to Omaha (Nebraska) | 1,295.63 mi (2,085.11 km) |
| Fort Myers to On Top of the World Designated Place (Florida) | 174.04 mi (280.09 km) |
| Fort Myers to Onalaska (Wisconsin) | 1,303.09 mi (2,097.12 km) |
| Fort Myers to Oneida (New York) | 1,188.79 mi (1,913.17 km) |
| Fort Myers to Oneonta (New York) | 1,158.87 mi (1,865.03 km) |
| Fort Myers to Ontario (California) | 2,182.50 mi (3,512.40 km) |
| Fort Myers to Ontario (Oregon) | 2,292.08 mi (3,688.75 km) |
| Fort Myers to Opa-locka (Florida) | 109.53 mi (176.28 km) |
| Fort Myers to Opelika (Alabama) | 468.55 mi (754.06 km) |
| Fort Myers to Opelousas (Louisiana) | 677.67 mi (1,090.61 km) |
| Fort Myers to Orange (California) | 2,193.82 mi (3,530.62 km) |
| Fort Myers to Orange (Texas) | 764.15 mi (1,229.78 km) |
| Fort Myers to Orange City (Florida) | 163.37 mi (262.93 km) |
| Fort Myers to Orangeburg (South Carolina) | 478.38 mi (769.87 km) |
