| Fort Myers to Santa Rosa (California) | 2,494.10 mi (4,013.87 km) |
| Fort Myers to Santaquin (Utah) | 1,947.65 mi (3,134.44 km) |
| Fort Myers to Santee (California) | 2,142.42 mi (3,447.88 km) |
| Fort Myers to Sapulpa (Oklahoma) | 1,061.17 mi (1,707.79 km) |
| Fort Myers to Saraland (Alabama) | 479.07 mi (770.99 km) |
| Fort Myers to Sarasota (Florida) | 66.31 mi (106.72 km) |
| Fort Myers to Sarasota Springs (Florida) | 61.99 mi (99.77 km) |
| Fort Myers to Saratoga (California) | 2,448.41 mi (3,940.34 km) |
| Fort Myers to Saratoga Springs (New York) | 1,223.27 mi (1,968.66 km) |
| Fort Myers to Saratoga Springs (Utah) | 1,962.24 mi (3,157.93 km) |
| Fort Myers to Sartell (Minnesota) | 1,479.66 mi (2,381.28 km) |
| Fort Myers to Satellite Beach (Florida) | 131.44 mi (211.53 km) |
| Fort Myers to Sauk Rapids (Minnesota) | 1,476.75 mi (2,376.60 km) |
| Fort Myers to Sault Ste. Marie (Michigan) | 1,379.39 mi (2,219.92 km) |
| Fort Myers to Savage (Minnesota) | 1,406.94 mi (2,264.26 km) |
