| Fort Myers to Scottsboro (Alabama) | 608.35 mi (979.04 km) |
| Fort Myers to Scottsdale (Arizona) | 1,852.33 mi (2,981.04 km) |
| Fort Myers to Scranton (Pennsylvania) | 1,080.07 mi (1,738.21 km) |
| Fort Myers to Seabrook (Maryland) | 901.28 mi (1,450.47 km) |
| Fort Myers to Seabrook (Texas) | 829.12 mi (1,334.34 km) |
| Fort Myers to Seaford (New York) | 1,081.37 mi (1,740.30 km) |
| Fort Myers to Seagoville (Texas) | 975.85 mi (1,570.48 km) |
| Fort Myers to Seal Beach (California) | 2,207.95 mi (3,553.35 km) |
| Fort Myers to Searcy (Arkansas) | 835.44 mi (1,344.50 km) |
| Fort Myers to Seaside (California) | 2,432.97 mi (3,915.49 km) |
| Fort Myers to SeaTac (Washington) | 2,612.57 mi (4,204.53 km) |
| Fort Myers to Seattle (Washington) | 2,617.67 mi (4,212.74 km) |
| Fort Myers to Sebastian (Florida) | 115.41 mi (185.73 km) |
| Fort Myers to Sebring (Florida) | 63.64 mi (102.42 km) |
| Fort Myers to Secaucus (New Jersey) | 1,074.30 mi (1,728.93 km) |
