| Fort Myers to Southern Pines (North Carolina) | 609.50 mi (980.90 km) |
| Fort Myers to Southfield (Michigan) | 1,098.59 mi (1,768.01 km) |
| Fort Myers to Southgate (Michigan) | 1,079.65 mi (1,737.53 km) |
| Fort Myers to Southlake (Texas) | 1,016.16 mi (1,635.35 km) |
| Fort Myers to Spanaway (Washington) | 2,610.49 mi (4,201.18 km) |
| Fort Myers to Spanish Fork (Utah) | 1,943.15 mi (3,127.20 km) |
| Fort Myers to Spanish Lake (Missouri) | 970.59 mi (1,562.02 km) |
| Fort Myers to Spanish Springs (Nevada) | 2,345.87 mi (3,775.32 km) |
| Fort Myers to Sparks (Nevada) | 2,347.24 mi (3,777.51 km) |
| Fort Myers to Spartanburg (South Carolina) | 575.22 mi (925.72 km) |
| Fort Myers to Spearfish (South Dakota) | 1,736.09 mi (2,793.97 km) |
| Fort Myers to Speedway (Indiana) | 945.05 mi (1,520.92 km) |
| Fort Myers to Spencer (Iowa) | 1,365.15 mi (2,197.00 km) |
| Fort Myers to Spokane (Washington) | 2,407.28 mi (3,874.14 km) |
| Fort Myers to Spokane Valley (Washington) | 2,398.74 mi (3,860.41 km) |
