| Grande-Synthe to Sangeorz-Bai | 1,036.90 mi (1,668.73 km) |
| Grande-Synthe to Sannicolau Mare | 901.74 mi (1,451.20 km) |
| Grande-Synthe to Santana | 929.86 mi (1,496.46 km) |
| Grande-Synthe to Satu Mare | 948.67 mi (1,526.73 km) |
| Grande-Synthe to Scobinti | 1,134.24 mi (1,825.38 km) |
| Grande-Synthe to Scornicesti | 1,118.96 mi (1,800.79 km) |
| Grande-Synthe to Sebes | 1,030.22 mi (1,657.98 km) |
| Grande-Synthe to Seini | 966.83 mi (1,555.96 km) |
| Grande-Synthe to Sfantu-Gheorghe | 1,128.09 mi (1,815.49 km) |
| Grande-Synthe to Sibiu | 1,060.38 mi (1,706.51 km) |
| Grande-Synthe to Sighetu Marmatiei | 988.68 mi (1,591.13 km) |
| Grande-Synthe to Sighisoara | 1,074.43 mi (1,729.13 km) |
| Grande-Synthe to Simeria | 1,009.97 mi (1,625.38 km) |
| Grande-Synthe to Sinaia | 1,134.49 mi (1,825.79 km) |
| Grande-Synthe to Slatina | 1,116.24 mi (1,796.42 km) |
