| Grosse Pointe Park to Senftenberg | 4,272.25 mi (6,875.52 km) |
| Grosse Pointe Park to Siegburg | 4,047.67 mi (6,514.10 km) |
| Grosse Pointe Park to Siegen | 4,075.43 mi (6,558.77 km) |
| Grosse Pointe Park to Sigmaringen | 4,222.34 mi (6,795.20 km) |
| Grosse Pointe Park to Simbach am Inn | 4,361.42 mi (7,019.02 km) |
| Grosse Pointe Park to Simmerath | 4,020.26 mi (6,469.98 km) |
| Grosse Pointe Park to Sindelfingen | 4,190.91 mi (6,744.62 km) |
| Grosse Pointe Park to Sinsheim | 4,166.69 mi (6,705.63 km) |
| Grosse Pointe Park to Sinzheim | 4,156.79 mi (6,689.71 km) |
| Grosse Pointe Park to Sinzig | 4,058.35 mi (6,531.29 km) |
| Grosse Pointe Park to Soest | 4,054.89 mi (6,525.72 km) |
| Grosse Pointe Park to Solingen | 4,030.52 mi (6,486.50 km) |
| Grosse Pointe Park to Soltau | 4,068.54 mi (6,547.69 km) |
| Grosse Pointe Park to Sommerda | 4,180.54 mi (6,727.93 km) |
| Grosse Pointe Park to Sondershausen | 4,163.85 mi (6,701.08 km) |
