| Grosse Pointe Park to Sacile | 4,432.35 mi (7,133.18 km) |
| Grosse Pointe Park to Sala Consilina | 4,788.36 mi (7,706.13 km) |
| Grosse Pointe Park to Salemi | 4,781.59 mi (7,695.23 km) |
| Grosse Pointe Park to Salerno | 4,741.75 mi (7,631.10 km) |
| Grosse Pointe Park to Salo | 4,368.94 mi (7,031.14 km) |
| Grosse Pointe Park to Salsomaggiore Terme | 4,377.30 mi (7,044.58 km) |
| Grosse Pointe Park to Saluzzo | 4,282.27 mi (6,891.64 km) |
| Grosse Pointe Park to Salzano | 4,434.50 mi (7,136.64 km) |
| Grosse Pointe Park to Samarate | 4,298.07 mi (6,917.08 km) |
| Grosse Pointe Park to San Benedetto del Tronto | 4,610.32 mi (7,419.59 km) |
| Grosse Pointe Park to San Biagio di Callalta | 4,438.85 mi (7,143.64 km) |
| Grosse Pointe Park to San Bonifacio | 4,406.69 mi (7,091.89 km) |
| Grosse Pointe Park to San Casciano in Val di Pesa | 4,472.05 mi (7,197.06 km) |
| Grosse Pointe Park to San Cataldo | 4,846.60 mi (7,799.85 km) |
| Grosse Pointe Park to San Cesareo | 4,613.20 mi (7,424.23 km) |
