| Grosse Pointe Park to Savignano sul Rubicone | 4,503.55 mi (7,247.77 km) |
| Grosse Pointe Park to Savona | 4,335.84 mi (6,977.86 km) |
| Grosse Pointe Park to Scafati | 4,728.97 mi (7,610.55 km) |
| Grosse Pointe Park to Scalea | 4,821.85 mi (7,760.01 km) |
| Grosse Pointe Park to Scandiano | 4,414.65 mi (7,104.69 km) |
| Grosse Pointe Park to Scandicci | 4,468.29 mi (7,191.01 km) |
| Grosse Pointe Park to Schio | 4,397.32 mi (7,076.80 km) |
| Grosse Pointe Park to Sciacca | 4,807.16 mi (7,736.37 km) |
| Grosse Pointe Park to Scicli | 4,907.48 mi (7,897.82 km) |
| Grosse Pointe Park to Scordia | 4,891.55 mi (7,872.20 km) |
| Grosse Pointe Park to Scorze | 4,432.66 mi (7,133.67 km) |
| Grosse Pointe Park to Sedico | 4,410.69 mi (7,098.33 km) |
| Grosse Pointe Park to Sedriano | 4,310.56 mi (6,937.17 km) |
| Grosse Pointe Park to Segni | 4,627.67 mi (7,447.51 km) |
| Grosse Pointe Park to Segrate | 4,323.55 mi (6,958.08 km) |
