| Grosse Pointe Park to Sestu | 4,560.05 mi (7,338.69 km) |
| Grosse Pointe Park to Settimo Torinese | 4,275.14 mi (6,880.17 km) |
| Grosse Pointe Park to Seveso | 4,311.32 mi (6,938.40 km) |
| Grosse Pointe Park to Sezze | 4,637.36 mi (7,463.12 km) |
| Grosse Pointe Park to Siano | 4,733.86 mi (7,618.40 km) |
| Grosse Pointe Park to Siena | 4,491.58 mi (7,228.50 km) |
| Grosse Pointe Park to Signa | 4,463.49 mi (7,183.30 km) |
| Grosse Pointe Park to Silea | 4,436.78 mi (7,140.31 km) |
| Grosse Pointe Park to Silvi Paese | 4,636.44 mi (7,461.63 km) |
| Grosse Pointe Park to Sinalunga | 4,512.09 mi (7,261.51 km) |
| Grosse Pointe Park to Siniscola | 4,534.20 mi (7,297.08 km) |
| Grosse Pointe Park to Sinnai | 4,564.72 mi (7,346.21 km) |
| Grosse Pointe Park to Siracusa | 4,920.29 mi (7,918.44 km) |
| Grosse Pointe Park to Solaro | 4,310.25 mi (6,936.68 km) |
| Grosse Pointe Park to Soliera | 4,418.45 mi (7,110.80 km) |
