| Grosse Pointe Park to Ede | 3,947.72 mi (6,353.24 km) |
| Grosse Pointe Park to Eemnes | 3,925.62 mi (6,317.67 km) |
| Grosse Pointe Park to Eerbeek | 3,960.69 mi (6,374.11 km) |
| Grosse Pointe Park to Eersel | 3,957.67 mi (6,369.26 km) |
| Grosse Pointe Park to Eijsden | 3,991.67 mi (6,423.98 km) |
| Grosse Pointe Park to Eindhoven | 3,961.21 mi (6,374.95 km) |
| Grosse Pointe Park to Elburg | 3,941.40 mi (6,343.06 km) |
| Grosse Pointe Park to Emmeloord | 3,929.24 mi (6,323.50 km) |
| Grosse Pointe Park to Emmen | 3,969.07 mi (6,387.60 km) |
| Grosse Pointe Park to Enkhuizen | 3,912.89 mi (6,297.19 km) |
| Grosse Pointe Park to Enschede | 3,988.02 mi (6,418.10 km) |
| Grosse Pointe Park to Epe | 3,949.63 mi (6,356.31 km) |
| Grosse Pointe Park to Ermelo | 3,937.65 mi (6,337.03 km) |
| Grosse Pointe Park to Etten-Leur | 3,924.67 mi (6,316.14 km) |
| Grosse Pointe Park to Franeker | 3,905.38 mi (6,285.09 km) |
