| Guadalajara to Spello | 830.46 mi (1,336.49 km) |
| Guadalajara to Spilamberto | 768.99 mi (1,237.58 km) |
| Guadalajara to Spilimbergo | 888.87 mi (1,430.49 km) |
| Guadalajara to Spinea | 841.69 mi (1,354.58 km) |
| Guadalajara to Spoleto | 829.63 mi (1,335.16 km) |
| Guadalajara to Spoltore | 902.19 mi (1,451.94 km) |
| Guadalajara to Spresiano | 852.19 mi (1,371.47 km) |
| Guadalajara to Squinzano | 1,111.56 mi (1,788.88 km) |
| Guadalajara to Statte | 1,066.09 mi (1,715.71 km) |
| Guadalajara to Stezzano | 732.20 mi (1,178.36 km) |
| Guadalajara to Strada | 768.77 mi (1,237.21 km) |
| Guadalajara to Stradella | 701.28 mi (1,128.60 km) |
| Guadalajara to Striano | 927.10 mi (1,492.02 km) |
| Guadalajara to Subiaco | 848.08 mi (1,364.85 km) |
| Guadalajara to Sulmona | 890.59 mi (1,433.26 km) |
