| Guadarrama to Sacile | 908.32 mi (1,461.81 km) |
| Guadarrama to Sala Consilina | 1,031.88 mi (1,660.65 km) |
| Guadarrama to Salemi | 923.45 mi (1,486.15 km) |
| Guadarrama to Salerno | 985.77 mi (1,586.44 km) |
| Guadarrama to Salo | 810.45 mi (1,304.29 km) |
| Guadarrama to Salsomaggiore Terme | 767.81 mi (1,235.67 km) |
| Guadarrama to Saluzzo | 648.44 mi (1,043.57 km) |
| Guadarrama to Salzano | 881.80 mi (1,419.13 km) |
| Guadarrama to Samarate | 732.12 mi (1,178.23 km) |
| Guadarrama to San Benedetto del Tronto | 936.94 mi (1,507.86 km) |
| Guadarrama to San Biagio di Callalta | 897.11 mi (1,443.77 km) |
| Guadarrama to San Bonifacio | 840.49 mi (1,352.64 km) |
| Guadarrama to San Casciano in Val di Pesa | 807.67 mi (1,299.82 km) |
| Guadarrama to San Cataldo | 992.13 mi (1,596.68 km) |
| Guadarrama to San Cesareo | 879.52 mi (1,415.46 km) |
