| Heidelberg to Siegburg | 116.80 mi (187.97 km) |
| Heidelberg to Siegen | 105.96 mi (170.53 km) |
| Heidelberg to Sigmaringen | 94.67 mi (152.36 km) |
| Heidelberg to Simbach am Inn | 211.02 mi (339.61 km) |
| Heidelberg to Simmerath | 134.91 mi (217.11 km) |
| Heidelberg to Sindelfingen | 50.30 mi (80.94 km) |
| Heidelberg to Sinsheim | 13.75 mi (22.12 km) |
| Heidelberg to Sinzheim | 51.63 mi (83.09 km) |
| Heidelberg to Sinzig | 101.56 mi (163.45 km) |
| Heidelberg to Soest | 151.23 mi (243.38 km) |
| Heidelberg to Solingen | 140.77 mi (226.55 km) |
| Heidelberg to Soltau | 251.12 mi (404.13 km) |
| Heidelberg to Sommerda | 160.49 mi (258.29 km) |
| Heidelberg to Sondershausen | 164.67 mi (265.01 km) |
| Heidelberg to Sonneberg | 126.70 mi (203.90 km) |
