| Highgate to Southern Pines (North Carolina) | 3,931.19 mi (6,326.63 km) |
| Highgate to Southfield (Michigan) | 3,749.73 mi (6,034.61 km) |
| Highgate to Southgate (Michigan) | 3,759.82 mi (6,050.85 km) |
| Highgate to Southlake (Texas) | 4,749.77 mi (7,644.01 km) |
| Highgate to Spanaway (Washington) | 4,811.78 mi (7,743.81 km) |
| Highgate to Spanish Fork (Utah) | 4,884.88 mi (7,861.46 km) |
| Highgate to Spanish Lake (Missouri) | 4,190.17 mi (6,743.43 km) |
| Highgate to Spanish Springs (Nevada) | 5,160.18 mi (8,304.50 km) |
| Highgate to Sparks (Nevada) | 5,166.33 mi (8,314.41 km) |
| Highgate to Spartanburg (South Carolina) | 4,046.38 mi (6,512.02 km) |
| Highgate to Spearfish (South Dakota) | 4,396.24 mi (7,075.06 km) |
| Highgate to Speedway (Indiana) | 3,989.08 mi (6,419.81 km) |
| Highgate to Spencer (Iowa) | 4,163.21 mi (6,700.03 km) |
| Highgate to Spokane (Washington) | 4,644.36 mi (7,474.38 km) |
| Highgate to Spokane Valley (Washington) | 4,639.07 mi (7,465.86 km) |
