| Highland Springs to Southern Pines (North Carolina) | 199.72 mi (321.42 km) |
| Highland Springs to Southfield (Michigan) | 462.71 mi (744.66 km) |
| Highland Springs to Southgate (Michigan) | 447.52 mi (720.21 km) |
| Highland Springs to Southlake (Texas) | 1,160.10 mi (1,867.00 km) |
| Highland Springs to Spanaway (Washington) | 2,360.42 mi (3,798.73 km) |
| Highland Springs to Spanish Fork (Utah) | 1,843.77 mi (2,967.26 km) |
| Highland Springs to Spanish Lake (Missouri) | 704.20 mi (1,133.30 km) |
| Highland Springs to Spanish Springs (Nevada) | 2,269.58 mi (3,652.54 km) |
| Highland Springs to Sparks (Nevada) | 2,273.05 mi (3,658.12 km) |
| Highland Springs to Spartanburg (South Carolina) | 313.07 mi (503.84 km) |
| Highland Springs to Spearfish (South Dakota) | 1,453.93 mi (2,339.87 km) |
| Highland Springs to Speedway (Indiana) | 505.21 mi (813.05 km) |
| Highland Springs to Spencer (Iowa) | 1,012.53 mi (1,629.51 km) |
| Highland Springs to Spokane (Washington) | 2,128.39 mi (3,425.31 km) |
| Highland Springs to Spokane Valley (Washington) | 2,119.16 mi (3,410.46 km) |
