| Washington (District of Columbia) to Sikeston | 698.89 mi (1,124.76 km) |
| Baltimore (Maryland) to Sikeston | 724.26 mi (1,165.59 km) |
| Tampa (Florida) to Sikeston | 741.63 mi (1,193.54 km) |
| Philadelphia (Pennsylvania) to Sikeston | 810.30 mi (1,304.05 km) |
| Denver (Colorado) to Sikeston | 851.03 mi (1,369.60 km) |
| Brooklyn (New York) to Sikeston | 880.28 mi (1,416.67 km) |
| New York (New York) to Sikeston | 882.19 mi (1,419.75 km) |
| Queens (New York) to Sikeston | 889.52 mi (1,431.55 km) |
| Miami (Florida) to Sikeston | 944.67 mi (1,520.30 km) |
| Boston (Massachusetts) to Sikeston | 1,051.42 mi (1,692.09 km) |
| Phoenix (Arizona) to Sikeston | 1,287.30 mi (2,071.71 km) |
| Las Vegas (Nevada) to Sikeston | 1,421.49 mi (2,287.66 km) |
| Riverside (California) to Sikeston | 1,573.43 mi (2,532.19 km) |
| San Diego (California) to Sikeston | 1,580.33 mi (2,543.29 km) |
| Los Angeles (California) to Sikeston | 1,626.13 mi (2,617.01 km) |
| San Francisco (California) to Sikeston | 1,797.09 mi (2,892.13 km) |
| Portland (Oregon) to Sikeston | 1,804.44 mi (2,903.96 km) |
| Seattle (Washington) to Sikeston | 1,813.76 mi (2,918.96 km) |
| St. Louis (Missouri) to Sikeston | 126.16 mi (203.04 km) |
| Chicago (Illinois) to Sikeston | 356.88 mi (574.35 km) |
| Atlanta (Georgia) to Sikeston | 362.32 mi (583.10 km) |
| Dallas (Texas) to Sikeston | 495.41 mi (797.28 km) |
| Detroit (Michigan) to Sikeston | 512.89 mi (825.42 km) |
| Minneapolis (Minnesota) to Sikeston | 590.11 mi (949.69 km) |
| Houston (Texas) to Sikeston | 593.61 mi (955.33 km) |