| Hilton Head Island to Sestu | 4,848.32 mi (7,802.61 km) |
| Hilton Head Island to Settimo Torinese | 4,619.39 mi (7,434.19 km) |
| Hilton Head Island to Seveso | 4,666.46 mi (7,509.94 km) |
| Hilton Head Island to Sezze | 4,967.28 mi (7,994.07 km) |
| Hilton Head Island to Siano | 5,064.67 mi (8,150.79 km) |
| Hilton Head Island to Siena | 4,831.92 mi (7,776.23 km) |
| Hilton Head Island to Signa | 4,807.57 mi (7,737.04 km) |
| Hilton Head Island to Silea | 4,804.84 mi (7,732.64 km) |
| Hilton Head Island to Silvi Paese | 4,981.64 mi (8,017.17 km) |
| Hilton Head Island to Sinalunga | 4,853.18 mi (7,810.44 km) |
| Hilton Head Island to Siniscola | 4,838.74 mi (7,787.21 km) |
| Hilton Head Island to Sinnai | 4,853.57 mi (7,811.07 km) |
| Hilton Head Island to Siracusa | 5,217.72 mi (8,397.11 km) |
| Hilton Head Island to Solaro | 4,664.88 mi (7,507.40 km) |
| Hilton Head Island to Soliera | 4,771.54 mi (7,679.05 km) |
