| Hilton Head Island to Sesena | 4,199.29 mi (6,758.11 km) |
| Hilton Head Island to Sestao | 4,163.21 mi (6,700.04 km) |
| Hilton Head Island to Sevilla | 4,147.97 mi (6,675.51 km) |
| Hilton Head Island to Sevilla La Nueva | 4,177.33 mi (6,722.77 km) |
| Hilton Head Island to Silla | 4,380.95 mi (7,050.46 km) |
| Hilton Head Island to Silleda | 3,921.85 mi (6,311.61 km) |
| Hilton Head Island to Sitges | 4,442.91 mi (7,150.17 km) |
| Hilton Head Island to Socuellamos | 4,263.29 mi (6,861.10 km) |
| Hilton Head Island to Soller | 4,524.42 mi (7,281.35 km) |
| Hilton Head Island to Solsona | 4,410.18 mi (7,097.49 km) |
| Hilton Head Island to Son Servera | 4,560.68 mi (7,339.71 km) |
| Hilton Head Island to Sonseca | 4,195.82 mi (6,752.51 km) |
| Hilton Head Island to Sopelana | 4,162.99 mi (6,699.68 km) |
| Hilton Head Island to Soria | 4,222.74 mi (6,795.85 km) |
| Hilton Head Island to Suances | 4,110.63 mi (6,615.41 km) |
