| Holbrook to Elyria (Ohio) | 472.07 mi (759.73 km) |
| Holbrook to Emeryville (California) | 2,604.51 mi (4,191.55 km) |
| Holbrook to Emmaus (Pennsylvania) | 128.49 mi (206.78 km) |
| Holbrook to Emporia (Kansas) | 1,238.42 mi (1,993.04 km) |
| Holbrook to Encinitas (California) | 2,471.89 mi (3,978.13 km) |
| Holbrook to Endicott (New York) | 179.30 mi (288.56 km) |
| Holbrook to Endwell (New York) | 178.12 mi (286.66 km) |
| Holbrook to Englewood (Colorado) | 1,676.78 mi (2,698.52 km) |
| Holbrook to Englewood (Florida) | 1,091.87 mi (1,757.19 km) |
| Holbrook to Englewood (New Jersey) | 47.71 mi (76.78 km) |
| Holbrook to Englewood (Ohio) | 594.94 mi (957.47 km) |
| Holbrook to Enid (Oklahoma) | 1,368.09 mi (2,201.73 km) |
| Holbrook to Ennis (Texas) | 1,426.83 mi (2,296.25 km) |
| Holbrook to Ensley (Florida) | 1,064.74 mi (1,713.53 km) |
| Holbrook to Enterprise (Alabama) | 966.10 mi (1,554.79 km) |
