| Holbrook to Enterprise (Nevada) | 2,284.33 mi (3,676.27 km) |
| Holbrook to Enumclaw (Washington) | 2,430.42 mi (3,911.38 km) |
| Holbrook to Ephrata (Pennsylvania) | 168.88 mi (271.79 km) |
| Holbrook to Erie (Colorado) | 1,673.18 mi (2,692.73 km) |
| Holbrook to Erie (Pennsylvania) | 373.86 mi (601.67 km) |
| Holbrook to Erlanger (Kentucky) | 622.24 mi (1,001.40 km) |
| Holbrook to Escanaba (Michigan) | 782.50 mi (1,259.31 km) |
| Holbrook to Escondido (California) | 2,459.49 mi (3,958.17 km) |
| Holbrook to Española (New Mexico) | 1,806.18 mi (2,906.77 km) |
| Holbrook to Essex (Maryland) | 206.12 mi (331.72 km) |
| Holbrook to Essex Junction (Vermont) | 255.36 mi (410.97 km) |
| Holbrook to Estelle (Louisiana) | 1,218.62 mi (1,961.17 km) |
| Holbrook to Estero (Florida) | 1,110.94 mi (1,787.88 km) |
| Holbrook to Euclid (Ohio) | 442.52 mi (712.17 km) |
| Holbrook to Eufaula (Alabama) | 908.70 mi (1,462.41 km) |
