| Holbrook to Olympia Heights (Florida) | 1,121.69 mi (1,805.18 km) |
| Holbrook to Omaha (Nebraska) | 1,194.87 mi (1,922.96 km) |
| Holbrook to On Top of the World Designated Place (Florida) | 960.28 mi (1,545.42 km) |
| Holbrook to Onalaska (Wisconsin) | 948.53 mi (1,526.51 km) |
| Holbrook to Oneida (New York) | 206.43 mi (332.22 km) |
| Holbrook to Oneonta (New York) | 154.26 mi (248.26 km) |
| Holbrook to Ontario (California) | 2,461.16 mi (3,960.85 km) |
| Holbrook to Ontario (Oregon) | 2,224.35 mi (3,579.75 km) |
| Holbrook to Opa-locka (Florida) | 1,108.50 mi (1,783.96 km) |
| Holbrook to Opelika (Alabama) | 881.78 mi (1,419.09 km) |
| Holbrook to Opelousas (Louisiana) | 1,277.16 mi (2,055.40 km) |
| Holbrook to Orange (California) | 2,479.13 mi (3,989.78 km) |
| Holbrook to Orange (Texas) | 1,372.85 mi (2,209.39 km) |
| Holbrook to Orange City (Florida) | 941.53 mi (1,515.24 km) |
| Holbrook to Orangeburg (South Carolina) | 661.92 mi (1,065.26 km) |
