| Holyhead to Sacile | 915.64 mi (1,473.58 km) |
| Holyhead to Sala Consilina | 1,298.96 mi (2,090.47 km) |
| Holyhead to Salemi | 1,355.07 mi (2,180.78 km) |
| Holyhead to Salerno | 1,255.86 mi (2,021.12 km) |
| Holyhead to Salo | 861.73 mi (1,386.82 km) |
| Holyhead to Salsomaggiore Terme | 881.33 mi (1,418.36 km) |
| Holyhead to Saluzzo | 810.62 mi (1,304.57 km) |
| Holyhead to Salzano | 921.20 mi (1,482.52 km) |
| Holyhead to Samarate | 801.07 mi (1,289.20 km) |
| Holyhead to San Benedetto del Tronto | 1,108.37 mi (1,783.76 km) |
| Holyhead to San Biagio di Callalta | 923.82 mi (1,486.74 km) |
| Holyhead to San Bonifacio | 897.61 mi (1,444.57 km) |
| Holyhead to San Casciano in Val di Pesa | 980.68 mi (1,578.25 km) |
| Holyhead to San Cataldo | 1,409.44 mi (2,268.27 km) |
| Holyhead to San Cesareo | 1,130.55 mi (1,819.45 km) |
