| Holyhead to Santa Venerina | 1,433.18 mi (2,306.48 km) |
| Holyhead to Santeramo in Colle | 1,318.11 mi (2,121.29 km) |
| Holyhead to Santo Stefano di Magra | 912.67 mi (1,468.80 km) |
| Holyhead to Santo Stino di Livenza | 932.77 mi (1,501.16 km) |
| Holyhead to Sarezzo | 847.71 mi (1,364.26 km) |
| Holyhead to Sarno | 1,243.85 mi (2,001.78 km) |
| Holyhead to Saronno | 809.13 mi (1,302.17 km) |
| Holyhead to Sarzana | 916.68 mi (1,475.25 km) |
| Holyhead to Sassari | 1,064.94 mi (1,713.86 km) |
| Holyhead to Sasso Marconi | 945.10 mi (1,520.99 km) |
| Holyhead to Sassuolo | 921.71 mi (1,483.35 km) |
| Holyhead to Sava | 1,366.68 mi (2,199.45 km) |
| Holyhead to Saviano | 1,235.19 mi (1,987.85 km) |
| Holyhead to Savigliano | 814.71 mi (1,311.15 km) |
| Holyhead to Savignano sul Panaro | 933.55 mi (1,502.40 km) |
