| Holyhead to Savignano sul Rubicone | 999.95 mi (1,609.27 km) |
| Holyhead to Savona | 859.29 mi (1,382.89 km) |
| Holyhead to Scafati | 1,244.17 mi (2,002.30 km) |
| Holyhead to Scalea | 1,336.80 mi (2,151.37 km) |
| Holyhead to Scandiano | 916.35 mi (1,474.73 km) |
| Holyhead to Scandicci | 975.78 mi (1,570.36 km) |
| Holyhead to Schio | 885.62 mi (1,425.26 km) |
| Holyhead to Sciacca | 1,381.47 mi (2,223.26 km) |
| Holyhead to Scicli | 1,471.12 mi (2,367.53 km) |
| Holyhead to Scordia | 1,446.28 mi (2,327.57 km) |
| Holyhead to Scorze | 919.14 mi (1,479.22 km) |
| Holyhead to Sedico | 894.27 mi (1,439.18 km) |
| Holyhead to Sedriano | 813.87 mi (1,309.79 km) |
| Holyhead to Segni | 1,144.77 mi (1,842.32 km) |
| Holyhead to Segrate | 824.55 mi (1,326.98 km) |
