| Holyhead to Selargius | 1,168.97 mi (1,881.27 km) |
| Holyhead to Selvazzano Dentro | 916.17 mi (1,474.43 km) |
| Holyhead to Senago | 814.46 mi (1,310.75 km) |
| Holyhead to Senigallia | 1,047.21 mi (1,685.32 km) |
| Holyhead to Seravezza | 931.51 mi (1,499.12 km) |
| Holyhead to Seregno | 813.41 mi (1,309.06 km) |
| Holyhead to Seriate | 829.37 mi (1,334.74 km) |
| Holyhead to Sermoneta | 1,150.80 mi (1,852.04 km) |
| Holyhead to Serramanna | 1,152.54 mi (1,854.83 km) |
| Holyhead to Serravalle Pistoiese | 956.44 mi (1,539.25 km) |
| Holyhead to Sessa Aurunca | 1,198.96 mi (1,929.54 km) |
| Holyhead to Sesto Calende | 790.25 mi (1,271.78 km) |
| Holyhead to Sesto Fiorentino | 972.08 mi (1,564.41 km) |
| Holyhead to Sesto San Giovanni | 820.31 mi (1,320.16 km) |
| Holyhead to Sestri Levante | 889.99 mi (1,432.30 km) |
