| Holyhead to Solofra | 1,250.76 mi (2,012.91 km) |
| Holyhead to Somma Lombardo | 794.97 mi (1,279.38 km) |
| Holyhead to Somma Vesuviana | 1,234.89 mi (1,987.36 km) |
| Holyhead to Sommacampagna | 882.37 mi (1,420.03 km) |
| Holyhead to Sona | 880.19 mi (1,416.53 km) |
| Holyhead to Sondrio | 811.53 mi (1,306.04 km) |
| Holyhead to Sora | 1,162.83 mi (1,871.39 km) |
| Holyhead to Sorbolo | 895.56 mi (1,441.27 km) |
| Holyhead to Soresina | 853.63 mi (1,373.78 km) |
| Holyhead to Sorisole | 824.70 mi (1,327.23 km) |
| Holyhead to Sorrento | 1,245.89 mi (2,005.07 km) |
| Holyhead to Sorso | 1,061.18 mi (1,707.81 km) |
| Holyhead to Sortino | 1,459.55 mi (2,348.92 km) |
| Holyhead to Soverato Marina | 1,423.08 mi (2,290.23 km) |
| Holyhead to Sovicille | 1,001.68 mi (1,612.05 km) |
