| Holyhead to Spello | 1,064.89 mi (1,713.78 km) |
| Holyhead to Spilamberto | 930.49 mi (1,497.47 km) |
| Holyhead to Spilimbergo | 922.84 mi (1,485.17 km) |
| Holyhead to Spinea | 924.63 mi (1,488.05 km) |
| Holyhead to Spoleto | 1,077.33 mi (1,733.79 km) |
| Holyhead to Spoltore | 1,142.29 mi (1,838.34 km) |
| Holyhead to Spresiano | 914.66 mi (1,472.00 km) |
| Holyhead to Squinzano | 1,382.03 mi (2,224.16 km) |
| Holyhead to Statte | 1,345.26 mi (2,164.98 km) |
| Holyhead to Stezzano | 828.79 mi (1,333.80 km) |
| Holyhead to Strada | 988.83 mi (1,591.37 km) |
| Holyhead to Stradella | 845.11 mi (1,360.08 km) |
| Holyhead to Striano | 1,242.18 mi (1,999.10 km) |
| Holyhead to Subiaco | 1,134.23 mi (1,825.37 km) |
| Holyhead to Sulmona | 1,155.91 mi (1,860.25 km) |
