| Holyhead to Schiedam | 390.69 mi (628.75 km) |
| Holyhead to Schijndel | 439.17 mi (706.78 km) |
| Holyhead to Schinnen | 474.35 mi (763.39 km) |
| Holyhead to Schoonhoven | 408.29 mi (657.08 km) |
| Holyhead to Simpelveld | 481.67 mi (775.17 km) |
| Holyhead to Sint Anthonis | 457.12 mi (735.66 km) |
| Holyhead to Sint Willebrord | 406.84 mi (654.74 km) |
| Holyhead to Sint-Michielsgestel | 435.54 mi (700.94 km) |
| Holyhead to Sint-Oedenrode | 441.52 mi (710.55 km) |
| Holyhead to Sittard | 472.29 mi (760.07 km) |
| Holyhead to Sliedrecht | 407.70 mi (656.14 km) |
| Holyhead to Slochteren | 472.04 mi (759.67 km) |
| Holyhead to Sluis | 365.62 mi (588.41 km) |
| Holyhead to Sneek | 426.36 mi (686.16 km) |
| Holyhead to Soest | 422.31 mi (679.63 km) |
