| Holyhead to Entroncamento | 973.45 mi (1,566.62 km) |
| Holyhead to Ericeira | 1,016.83 mi (1,636.43 km) |
| Holyhead to Ermezinde | 855.09 mi (1,376.13 km) |
| Holyhead to Esmoriz | 873.62 mi (1,405.96 km) |
| Holyhead to Espinho | 870.02 mi (1,400.17 km) |
| Holyhead to Esposende | 836.07 mi (1,345.52 km) |
| Holyhead to Estarreja | 886.95 mi (1,427.41 km) |
| Holyhead to Estoril | 1,034.10 mi (1,664.22 km) |
| Holyhead to Estremoz | 1,008.75 mi (1,623.43 km) |
| Holyhead to Evora | 1,030.34 mi (1,658.17 km) |
| Holyhead to Fafe | 835.62 mi (1,344.80 km) |
| Holyhead to Falagueira | 1,028.63 mi (1,655.42 km) |
| Holyhead to Famalicao | 841.22 mi (1,353.81 km) |
| Holyhead to Fanzeres | 858.34 mi (1,381.36 km) |
| Holyhead to Faro | 1,136.85 mi (1,829.59 km) |
