| Holyhead to Sesimbra | 1,048.80 mi (1,687.88 km) |
| Holyhead to Setubal | 1,041.37 mi (1,675.92 km) |
| Holyhead to Sever do Vouga | 886.20 mi (1,426.20 km) |
| Holyhead to Silves | 1,128.80 mi (1,816.63 km) |
| Holyhead to Sines | 1,079.91 mi (1,737.95 km) |
| Holyhead to Sintra | 1,027.55 mi (1,653.68 km) |
| Holyhead to Sobrado de Paiva | 864.88 mi (1,391.89 km) |
| Holyhead to Sobral de Monte Agraco | 1,010.30 mi (1,625.92 km) |
| Holyhead to Soure | 935.15 mi (1,504.97 km) |
| Holyhead to Tabua | 908.69 mi (1,462.39 km) |
| Holyhead to Tavira | 1,128.12 mi (1,815.53 km) |
| Holyhead to Tomar | 963.82 mi (1,551.12 km) |
| Holyhead to Tondela | 898.46 mi (1,445.94 km) |
| Holyhead to Torre de Moncorvo | 844.69 mi (1,359.40 km) |
| Holyhead to Torres Novas | 973.93 mi (1,567.39 km) |
