| Holyhead to Sangeorgiu de Mures | 1,364.52 mi (2,195.98 km) |
| Holyhead to Sangeorz-Bai | 1,345.21 mi (2,164.91 km) |
| Holyhead to Sannicolau Mare | 1,226.12 mi (1,973.25 km) |
| Holyhead to Santana | 1,251.14 mi (2,013.51 km) |
| Holyhead to Satu Mare | 1,258.00 mi (2,024.55 km) |
| Holyhead to Scobinti | 1,437.47 mi (2,313.39 km) |
| Holyhead to Scornicesti | 1,442.31 mi (2,321.18 km) |
| Holyhead to Sebes | 1,349.31 mi (2,171.50 km) |
| Holyhead to Seini | 1,275.58 mi (2,052.85 km) |
| Holyhead to Sfantu-Gheorghe | 1,443.12 mi (2,322.48 km) |
| Holyhead to Sibiu | 1,379.13 mi (2,219.49 km) |
| Holyhead to Sighetu Marmatiei | 1,294.73 mi (2,083.67 km) |
| Holyhead to Sighisoara | 1,389.63 mi (2,236.40 km) |
| Holyhead to Simeria | 1,330.72 mi (2,141.58 km) |
| Holyhead to Sinaia | 1,452.59 mi (2,337.71 km) |
