| Holyhead to Santa Ursula | 1,821.95 mi (2,932.15 km) |
| Holyhead to Santander | 681.35 mi (1,096.53 km) |
| Holyhead to Santany | 1,031.37 mi (1,659.83 km) |
| Holyhead to Santiago de Compostela | 742.69 mi (1,195.25 km) |
| Holyhead to Santiago del Teide | 1,836.03 mi (2,954.80 km) |
| Holyhead to Santiponce | 1,098.84 mi (1,768.42 km) |
| Holyhead to Santomera | 1,067.25 mi (1,717.57 km) |
| Holyhead to Santona | 683.89 mi (1,100.62 km) |
| Holyhead to Santurce-Antiguo | 693.33 mi (1,115.81 km) |
| Holyhead to Sarria | 738.38 mi (1,188.32 km) |
| Holyhead to Sauzal | 1,817.38 mi (2,924.80 km) |
| Holyhead to Sedavi | 979.85 mi (1,576.92 km) |
| Holyhead to Segorbe | 949.97 mi (1,528.84 km) |
| Holyhead to Segovia | 854.39 mi (1,375.01 km) |
| Holyhead to Senmanat | 867.11 mi (1,395.48 km) |
