| Houghton le Spring to Sestu | 1,180.20 mi (1,899.35 km) |
| Houghton le Spring to Settimo Torinese | 784.76 mi (1,262.96 km) |
| Houghton le Spring to Seveso | 787.77 mi (1,267.79 km) |
| Houghton le Spring to Sezze | 1,134.57 mi (1,825.92 km) |
| Houghton le Spring to Siano | 1,219.78 mi (1,963.05 km) |
| Houghton le Spring to Siena | 981.29 mi (1,579.23 km) |
| Houghton le Spring to Signa | 947.85 mi (1,525.42 km) |
| Houghton le Spring to Silea | 876.04 mi (1,409.84 km) |
| Houghton le Spring to Silvi Paese | 1,102.32 mi (1,774.01 km) |
| Houghton le Spring to Sinalunga | 997.86 mi (1,605.90 km) |
| Houghton le Spring to Siniscola | 1,110.93 mi (1,787.88 km) |
| Houghton le Spring to Sinnai | 1,182.14 mi (1,902.47 km) |
| Houghton le Spring to Siracusa | 1,459.86 mi (2,349.42 km) |
| Houghton le Spring to Solaro | 788.04 mi (1,268.23 km) |
| Houghton le Spring to Soliera | 887.70 mi (1,428.62 km) |
