| Houston to Enterprise (Nevada) | 1,225.84 mi (1,972.80 km) |
| Houston to Enumclaw (Washington) | 1,859.12 mi (2,991.96 km) |
| Houston to Ephrata (Pennsylvania) | 1,298.62 mi (2,089.92 km) |
| Houston to Erie (Colorado) | 893.76 mi (1,438.37 km) |
| Houston to Erie (Pennsylvania) | 1,204.49 mi (1,938.44 km) |
| Houston to Erlanger (Kentucky) | 884.97 mi (1,424.22 km) |
| Houston to Escanaba (Michigan) | 1,190.73 mi (1,916.29 km) |
| Houston to Escondido (California) | 1,296.30 mi (2,086.20 km) |
| Houston to Española (New Mexico) | 753.22 mi (1,212.18 km) |
| Houston to Essex (Maryland) | 1,258.85 mi (2,025.93 km) |
| Houston to Essex Junction (Vermont) | 1,583.62 mi (2,548.59 km) |
| Houston to Estelle (Louisiana) | 316.91 mi (510.01 km) |
| Houston to Estero (Florida) | 859.71 mi (1,383.56 km) |
| Houston to Euclid (Ohio) | 1,124.51 mi (1,809.73 km) |
| Houston to Eufaula (Alabama) | 624.51 mi (1,005.05 km) |
