| Houston to Sanford (Maine) | 1,649.42 mi (2,654.49 km) |
| Houston to Sanford (North Carolina) | 1,020.55 mi (1,642.42 km) |
| Houston to Sanger (California) | 1,471.24 mi (2,367.73 km) |
| Houston to Santa Ana (California) | 1,346.43 mi (2,166.86 km) |
| Houston to Santa Barbara (California) | 1,455.89 mi (2,343.03 km) |
| Houston to Santa Clara (California) | 1,610.70 mi (2,592.16 km) |
| Houston to Santa Clara (Oregon) | 1,810.35 mi (2,913.48 km) |
| Houston to Santa Clarita (California) | 1,386.50 mi (2,231.36 km) |
| Houston to Santa Cruz (California) | 1,609.38 mi (2,590.05 km) |
| Houston to Santa Fe (New Mexico) | 736.84 mi (1,185.82 km) |
| Houston to Santa Fe (Texas) | 32.44 mi (52.21 km) |
| Houston to Santa Fe Springs (California) | 1,358.10 mi (2,185.64 km) |
| Houston to Santa Maria (California) | 1,500.56 mi (2,414.91 km) |
| Houston to Santa Monica (California) | 1,382.59 mi (2,225.07 km) |
| Houston to Santa Paula (California) | 1,418.24 mi (2,282.43 km) |
