| Houston to Santa Rosa (California) | 1,665.57 mi (2,680.47 km) |
| Houston to Santaquin (Utah) | 1,162.91 mi (1,871.52 km) |
| Houston to Santee (California) | 1,289.90 mi (2,075.89 km) |
| Houston to Sapulpa (Oklahoma) | 431.95 mi (695.15 km) |
| Houston to Saraland (Alabama) | 440.76 mi (709.33 km) |
| Houston to Sarasota (Florida) | 797.16 mi (1,282.91 km) |
| Houston to Sarasota Springs (Florida) | 801.77 mi (1,290.33 km) |
| Houston to Saratoga (California) | 1,612.58 mi (2,595.19 km) |
| Houston to Saratoga Springs (New York) | 1,504.11 mi (2,420.64 km) |
| Houston to Saratoga Springs (Utah) | 1,182.22 mi (1,902.60 km) |
| Houston to Sartell (Minnesota) | 1,095.77 mi (1,763.47 km) |
| Houston to Satellite Beach (Florida) | 899.96 mi (1,448.34 km) |
| Houston to Sauk Rapids (Minnesota) | 1,094.56 mi (1,761.52 km) |
| Houston to Sault Ste. Marie (Michigan) | 1,296.71 mi (2,086.85 km) |
| Houston to Savage (Minnesota) | 1,040.11 mi (1,673.89 km) |
