| Houston to Scottsboro (Alabama) | 640.42 mi (1,030.66 km) |
| Houston to Scottsdale (Arizona) | 1,003.74 mi (1,615.36 km) |
| Houston to Scranton (Pennsylvania) | 1,362.91 mi (2,193.39 km) |
| Houston to Seabrook (Maryland) | 1,229.66 mi (1,978.94 km) |
| Houston to Seabrook (Texas) | 26.31 mi (42.35 km) |
| Houston to Seaford (New York) | 1,440.44 mi (2,318.16 km) |
| Houston to Seagoville (Texas) | 209.55 mi (337.24 km) |
| Houston to Seal Beach (California) | 1,357.38 mi (2,184.49 km) |
| Houston to Searcy (Arkansas) | 432.81 mi (696.55 km) |
| Houston to Seaside (California) | 1,593.46 mi (2,564.43 km) |
| Houston to SeaTac (Washington) | 1,880.13 mi (3,025.78 km) |
| Houston to Seattle (Washington) | 1,887.44 mi (3,037.53 km) |
| Houston to Sebastian (Florida) | 912.57 mi (1,468.64 km) |
| Houston to Sebring (Florida) | 859.46 mi (1,383.17 km) |
| Houston to Secaucus (New Jersey) | 1,416.56 mi (2,279.74 km) |
