| Houston to Southern Pines (North Carolina) | 1,002.16 mi (1,612.82 km) |
| Houston to Southfield (Michigan) | 1,105.17 mi (1,778.60 km) |
| Houston to Southgate (Michigan) | 1,093.04 mi (1,759.08 km) |
| Houston to Southlake (Texas) | 242.33 mi (389.99 km) |
| Houston to Spanaway (Washington) | 1,873.05 mi (3,014.38 km) |
| Houston to Spanish Fork (Utah) | 1,161.23 mi (1,868.82 km) |
| Houston to Spanish Lake (Missouri) | 688.41 mi (1,107.89 km) |
| Houston to Spanish Springs (Nevada) | 1,531.56 mi (2,464.81 km) |
| Houston to Sparks (Nevada) | 1,532.06 mi (2,465.62 km) |
| Houston to Spartanburg (South Carolina) | 861.77 mi (1,386.88 km) |
| Houston to Spearfish (South Dakota) | 1,115.50 mi (1,795.23 km) |
| Houston to Speedway (Indiana) | 863.29 mi (1,389.32 km) |
| Houston to Spencer (Iowa) | 923.23 mi (1,485.80 km) |
| Houston to Spokane (Washington) | 1,702.25 mi (2,739.51 km) |
| Houston to Spokane Valley (Washington) | 1,694.86 mi (2,727.62 km) |
