| Isabela to Spello | 4,843.15 mi (7,794.30 km) |
| Isabela to Spilamberto | 4,749.36 mi (7,643.36 km) |
| Isabela to Spilimbergo | 4,828.57 mi (7,770.83 km) |
| Isabela to Spinea | 4,798.44 mi (7,722.35 km) |
| Isabela to Spoleto | 4,845.82 mi (7,798.59 km) |
| Isabela to Spoltore | 4,921.91 mi (7,921.05 km) |
| Isabela to Spresiano | 4,800.70 mi (7,725.99 km) |
| Isabela to Squinzano | 5,145.18 mi (8,280.37 km) |
| Isabela to Statte | 5,099.59 mi (8,206.99 km) |
| Isabela to Stezzano | 4,676.67 mi (7,526.37 km) |
| Isabela to Strada | 4,770.73 mi (7,677.75 km) |
| Isabela to Stradella | 4,662.36 mi (7,503.34 km) |
| Isabela to Striano | 4,960.72 mi (7,983.51 km) |
| Isabela to Subiaco | 4,874.21 mi (7,844.29 km) |
| Isabela to Sulmona | 4,915.13 mi (7,910.13 km) |
