| Isabela to Entroncamento | 3,751.40 mi (6,037.29 km) |
| Isabela to Ericeira | 3,697.68 mi (5,950.85 km) |
| Isabela to Ermezinde | 3,758.84 mi (6,049.27 km) |
| Isabela to Esmoriz | 3,752.92 mi (6,039.74 km) |
| Isabela to Espinho | 3,752.65 mi (6,039.30 km) |
| Isabela to Esposende | 3,749.27 mi (6,033.86 km) |
| Isabela to Estarreja | 3,754.57 mi (6,042.40 km) |
| Isabela to Estoril | 3,697.16 mi (5,950.00 km) |
| Isabela to Estremoz | 3,795.41 mi (6,108.12 km) |
| Isabela to Evora | 3,777.05 mi (6,078.57 km) |
| Isabela to Fafe | 3,780.34 mi (6,083.87 km) |
| Isabela to Falagueira | 3,706.73 mi (5,965.41 km) |
| Isabela to Famalicao | 3,762.07 mi (6,054.47 km) |
| Isabela to Fanzeres | 3,759.33 mi (6,050.06 km) |
| Isabela to Faro | 3,768.88 mi (6,065.42 km) |
