| Isabela to Sesimbra | 3,711.73 mi (5,973.46 km) |
| Isabela to Setubal | 3,723.34 mi (5,992.13 km) |
| Isabela to Sever do Vouga | 3,764.87 mi (6,058.97 km) |
| Isabela to Silves | 3,741.77 mi (6,021.80 km) |
| Isabela to Sines | 3,721.91 mi (5,989.84 km) |
| Isabela to Sintra | 3,698.27 mi (5,951.79 km) |
| Isabela to Sobrado de Paiva | 3,772.17 mi (6,070.72 km) |
| Isabela to Sobral de Monte Agraco | 3,712.26 mi (5,974.30 km) |
| Isabela to Soure | 3,746.31 mi (6,029.10 km) |
| Isabela to Tabua | 3,780.04 mi (6,083.39 km) |
| Isabela to Tavira | 3,784.90 mi (6,091.21 km) |
| Isabela to Tomar | 3,754.93 mi (6,042.98 km) |
| Isabela to Tondela | 3,778.21 mi (6,080.44 km) |
| Isabela to Torre de Moncorvo | 3,832.00 mi (6,167.01 km) |
| Isabela to Torres Novas | 3,747.94 mi (6,031.73 km) |
