| Isabela to Sesena | 4,006.87 mi (6,448.43 km) |
| Isabela to Sestao | 4,053.71 mi (6,523.82 km) |
| Isabela to Sevilla | 3,876.55 mi (6,238.70 km) |
| Isabela to Sevilla La Nueva | 3,990.13 mi (6,421.49 km) |
| Isabela to Silla | 4,180.78 mi (6,728.31 km) |
| Isabela to Silleda | 3,786.83 mi (6,094.32 km) |
| Isabela to Sitges | 4,296.06 mi (6,913.84 km) |
| Isabela to Socuellamos | 4,053.35 mi (6,523.24 km) |
| Isabela to Soller | 4,345.77 mi (6,993.83 km) |
| Isabela to Solsona | 4,280.78 mi (6,889.24 km) |
| Isabela to Son Servera | 4,381.25 mi (7,050.94 km) |
| Isabela to Sonseca | 3,992.51 mi (6,425.32 km) |
| Isabela to Sopelana | 4,055.34 mi (6,526.45 km) |
| Isabela to Soria | 4,075.57 mi (6,558.99 km) |
| Isabela to Suances | 4,001.98 mi (6,440.57 km) |
