| Isabela to Des Plaines (Illinois) | 2,036.59 mi (3,277.57 km) |
| Isabela to Desert Hot Springs (California) | 3,215.49 mi (5,174.84 km) |
| Isabela to DeSoto (Texas) | 2,089.26 mi (3,362.33 km) |
| Isabela to Destin (Florida) | 1,469.93 mi (2,365.63 km) |
| Isabela to Destrehan (Louisiana) | 1,665.58 mi (2,680.50 km) |
| Isabela to Detroit (Michigan) | 1,900.52 mi (3,058.59 km) |
| Isabela to Diamond Bar (California) | 3,288.36 mi (5,292.11 km) |
| Isabela to Diamond Springs (California) | 3,493.05 mi (5,621.53 km) |
| Isabela to Dickinson (North Dakota) | 2,816.18 mi (4,532.21 km) |
| Isabela to Dickinson (Texas) | 1,918.35 mi (3,087.29 km) |
| Isabela to Dickson (Tennessee) | 1,734.36 mi (2,791.18 km) |
| Isabela to Difficult Run (Virginia) | 1,539.67 mi (2,477.86 km) |
| Isabela to Dinuba (California) | 3,396.19 mi (5,465.64 km) |
| Isabela to Discovery Bay (California) | 3,527.30 mi (5,676.65 km) |
| Isabela to Dix Hills (New York) | 1,585.89 mi (2,552.25 km) |
