| Isabela to Elyria (Ohio) | 1,814.14 mi (2,919.57 km) |
| Isabela to Emeryville (California) | 3,564.44 mi (5,736.41 km) |
| Isabela to Emmaus (Pennsylvania) | 1,603.56 mi (2,580.68 km) |
| Isabela to Emporia (Kansas) | 2,226.18 mi (3,582.69 km) |
| Isabela to Encinitas (California) | 3,250.41 mi (5,231.03 km) |
| Isabela to Endicott (New York) | 1,714.94 mi (2,759.93 km) |
| Isabela to Endwell (New York) | 1,715.49 mi (2,760.82 km) |
| Isabela to Englewood (Colorado) | 2,688.78 mi (4,327.18 km) |
| Isabela to Englewood (Florida) | 1,137.35 mi (1,830.38 km) |
| Isabela to Englewood (New Jersey) | 1,601.06 mi (2,576.65 km) |
| Isabela to Englewood (Ohio) | 1,799.94 mi (2,896.73 km) |
| Isabela to Enid (Oklahoma) | 2,244.14 mi (3,611.59 km) |
| Isabela to Ennis (Texas) | 2,070.19 mi (3,331.64 km) |
| Isabela to Ensley (Florida) | 1,516.15 mi (2,440.00 km) |
| Isabela to Enterprise (Alabama) | 1,471.47 mi (2,368.11 km) |
